Murphy Andrew J.,Thurston O. Gavin,Varghese Bindu,Gurer Cagan
申请号：
US201815866632
公开号：
US2018139941(A1)
申请日:
2018.01.10
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRPα gene. Genetically modified mice are described, including mice that express a human or humanized SIRPα protein from an endogenous SIRPα locus.
