KRISTALLINES (8S, 9R) -5-FLUOR-8- (4-FLUORPHENYL) -9- (1-METHYL-1H-1,2,4-TRIAZOL-5-YL) -8,9-DIHYDRO-2H-PYRIDO [4,3,2-DE] PHTALAZIN-3 (7H) -ON-TOSYLATSALZ

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专利权人:

Medivation Technologies LLC

发明人:

WANG, Bing,CHU, Daniel,LIU, Yongbo,PENG, Shichun

申请号：

EP11777005

公开号：

EP2630146B1

申请日:

2011.10.20

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

Provided herein are (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt forms, including crystalline forms, and methods of their preparation. Pharmaceutical compositions comprising a (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt are also provided, as are methods of using (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt to treat a disease or condition, such as a cancer.

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http://www.ckcest.cn/home/