CRYSTALLINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO&lsqb；4,3,2-DE&rsqb；PHTHALAZIN-3(7H)-ONE TOSYLATE SALT
WANG BING,왕 빙,CHU DANIEL,추 다니엘,LIU YONGBO,리우 용보,PENG SHICHUN,펭 시춘
申请号：
KR1020137012297
公开号：
KR1020140009181A
申请日:
2011.10.20
申请国别(地区):
KR
年份:
2014
代理人:
摘要：
Provided herein are (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt forms, including crystalline forms, and methods of their preparation. Pharmaceutical compositions comprising a (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt are also provided, as are methods of using (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt to treat a disease or condition, such as a cancer.본 발명은, 결정질 형태를 비롯하여, (8S,9R)-5-플루오로-8-(4-플루오로페닐)-9-(1-메틸-1H-1,2,4-트리아졸-5-일)-8,9-디하이드로-2H-피리도[4,3,2-de]프탈라진-3(7H)-온 토실레이트 염 형태들, 및 이의 제조 방법을 제공한다. 또한, (8S,9R)-5-플루오로-8-(4-플루오로페닐)-9-(1-메틸-1H-1,2,4-트리아졸-5-일)-8,9-디하이드로-2H-피리도[4,3,2-de]프탈라진-3(7H)-온 토실레이트 염을 포함하는 약학 조성물과, 암과 같은 질환 또는 병태를 치료하기 위해 (8S,9R)-5-플루오로-8-(4-플루오로페닐)-9-(1-메틸-1H-1,2,4-트리아졸-5-일)-8,9-디하이드로-2H-피리도[4,3,2-de]프탈라진-3(7H)-온 토실레이트 염을 사용하는 방법을 제공한다.
