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PIPERAZINE DERIVATIVES USED AS CAV2.2 CALCIUM CHANNEL MODULATORS
专利权人:
Convergence Pharmaceuticals Limited
发明人:
Beswick, Paul John,Campbell, Alister,Cridland, Andrew Peter,Gleave, Robert James,Heer, Jag Paul,Nicholson, Neville Hubert,Page, Lee William,Vile, Sadie
申请号:
AU2013242858
公开号:
AU2013242858B2
申请日:
2013.10.11
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
#$%^&*AU2013242858B220160317.pdf#####ABSTRACT A compound of formula (1), or a pharmaceutically acceptable salt thereof, for use in therapy, wherein: N T (R), N 0 0 N (R2 )m R6 \/ R 4 5 R R5 (1) m and n are independently selected from 0, 1 and 2 where present, each R1 is independently selected from C1_4 alkyl, C1_4 alkoxy, C3-6 cycloalkyl, cyano, NRlaRlb and halogen .0 R1l and Rlb are independently selected from hydrogen, C1_4 alkyl, C3-6 cycloalkyl and a 4 to 6 membered heterocyclyl or Rla and Rlb together with the nitrogen atom to which they are attached form a 4 to 6 membered heterocyclic ring where present, each R2 is C1_4 alkyl R3 is hydrogen, halogen, cyano, C1_4 haloalkyl or C1_4 haloalkoxy 15 R4 is hydrogen or C1_4 alkyl R5 is hydrogen, halogen, cyano, C1_4 haloalkyl or C1_4 haloalkoxy R6 is hydrogen, halogen, cyano, C1_4 haloalkyl or C1_4 haloalkoxy such that at least 1 of R3, R4, R5 and R6 is a group other than hydrogen.
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