A method for fabricating a biomedical frame uses a three-dimensional (3D) printer to print a porous substrate by using biodegradable polymer material. By using a computed tomography to obtain a 3D image of a damaged organism, the 3D image is examined to further obtain a 3D structure of the damaged portion. The porous substrate is firstly soaked in an agar liquid in order to let the agar liquid fully fills the tiny holes of the porous substrate, and then, the porous substrate is rapidly frozen by putting it into a liquid nitrogen environment. And then, the frozen porous substrate is processed and cut by a machine to form a customized frame having a 3D shape exactly fits the shape of the damaged portion. Once the agar liquid is melted, the frame becomes porous again and can be used to assist and guide the cells to regenerate and stick-on, so as to accelerate the regenerations and repairs of the hard tissues of damaged organism.一種生醫支架及其製造方法,藉由三維列印設備將生物可分解之高分子聚合物印製成具多孔隙的基材。結合醫療斷層掃瞄來取得破損生物組織的3D影像,進而獲得破損部位的三維結構。接著,先將多孔隙之基材浸泡於洋菜膠並使洋菜膠填滿該些孔隙後,再置入液態氮中使其急速冷凍。之後,再以加工機對冷凍狀態下的基材切削加工出客製化形狀且符合破損部位形狀的支架結構。一旦洋菜膠融化後,該支架又回復成多孔隙的結構,可引導細胞的貼附及增生,以促進生物硬組織的再生及修復。11~15、21~22‧‧‧步驟
