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PHARMACEUTICAL COMPOSITIONS (R) -1- (2, 2-DIFLUORBENZO [D] [1, 3] DIOXOL-5-IL) -N- (2, 3-DIHYDROXYPROPYL) -6-FLUOR-2- (1-HYDROXY- 2-METILPROPAN-2-IL) -1H-INDOL-5-IL) CYCLOPROPANOCARBOXAMIDE AND THEIR APPLICATION
专利权人:
ВЕРТЕКС ФАРМАСЬЮТИКАЛЗ ИНКОРПОРЕЙТЕД (US)
发明人:
АЛАРГОВА Россица Георгиева (US),ДАНБАР Крейг Энтони (US),КАДИЯЛА Ирина Николаевна (US)
申请号:
RU2013112937/15
公开号:
RU2013112937A
申请日:
2011.08.22
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A tablet for oral administration comprising: a. compound 1; b. filler; c. diluent; d. disintegrant; e. lubricant and f. glidant. 2. The tablet according to claim 1, where compound 1 is in the form of an amorphous form of compound 1.3. A tablet according to claim 1, wherein compound 1 or an amorphous form of compound 1 is present in said tablet in an amount of from about 1 mg to about 250 mg. A tablet according to claim 1, wherein compound 1 or an amorphous form of compound 1 is present in said tablet in an amount of from about 10 mg to about 250 mg. A tablet according to claim 1, wherein compound 1 or an amorphous form of compound 1 is present in said tablet in an amount of from about 25 mg to about 250 mg. The tablet according to claim 1, wherein compound 1 or an amorphous form of compound 1 is present in said tablet in an amount of from about 50 mg to about 200 mg. A tablet according to claim 1, wherein compound 1 or an amorphous form of compound 1 is present in said tablet in an amount of about 10 mg. A tablet according to claim 1, wherein compound 1 or an amorphous form of compound 1 is present in said tablet in an amount of about 50 mg. A tablet according to claim 1, wherein compound 1 or an amorphous form of compound 1 is present in said tablet in an amount of about 100 mg. The tablet according to claim 1, where the amount of compound 1 or an amorphous form of compound 1 in the specified tablet is in the range from about 1% of the mass. up to about 80% of the mass. based on the weight of the indicated tablet. 11. The tablet of claim 1, wherein the amount of compound 1 or an amorphous form of compound 1 in said tablet is in the range of about1. Таблетка для перорального введения, содержащая:а. соединение 1;b. наполнитель;с.разбавитель;d. дезинтегрант;е. лубрикант иf. глидант.2. Таблетка по п.1, где соединение 1 находится в виде аморфной формы соединения 1.3. Таблетка по п.1, где соединение 1 или аморфная форма соединения 1 присутствует в указанной таблетке в
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