#$%^&*AU2020200151A120200130.pdf#####ABSTRACT The present application provides single-domain antibodies, and chimeric antigen receptors comprising one or more antigen binding domains each comprising a single-domain antibody. Further provided are engineered immune effector cells (such as T cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating cancer are also provided. 12009003 1 (GHMatters) P108007.AU.1