Methods and compositions to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma

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专利权人:

MANNKIND CORPORATION

发明人:

QIU, ZHIYONG,BOT, ADRIAN

申请号：

EP11162841

公开号：

EP2385059A3

申请日:

2006.06.16

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The present invention provides a method of treating cancer by providing to a subject in need thereof an immunogenic composition comprising a nucleic acid construct encoding a polypeptide comprising CTL epitopes PSMA288-297 and PRAME425-433, or a cross-reactive analogue. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/