Methods and compositions to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma

• 收藏
• 分享

专利权人:

MannKind Corporation

发明人:

Qiu, Zhiyong,Bot, Adrian

申请号：

AU2006259220

公开号：

AU2006259220C1

申请日:

2006.06.16

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

The present invention provides a method of treating cancer by providing to a subject in need thereof an immunogenic composition comprising a nucleic acid construct encoding a polypeptide comprising CTL epitopes PSMA288-297 and PRAME425-433, or a cross-reactive analogue. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/