The present invention provides oligonucleotides that inhibit the binding of miR -27a to VE- cadherin mRNA, particularly in the form of blockmirs. The invention also provides compositions comprising such oligonucleotides and methods of use of such oligonucleotides to modulate the activity of VE cadherin , inhibit or reduce vascular permeability , treat or prevent a vascular permeability- associated disease or condition inhibit tumour growth , treat ischaemic injury , enhance recovery from ischaemic injury , treat surgical wounds and/or promotes post- operative recovery , and promote or induce angiogenesis.
