The multiple kinase inhibiter, concretely as for sorahuenibu, it is used in order to manufacture the pharmacy composition blood vessel permeability blood vessel permeability in order to make Shank decrease at the time of remedying of various unsound states where Shank is included.< Selective figure >It is notマルチキナーゼ阻害剤、具体的にはソラフェニブは、血管透過性亢進を減少させるための血管透過性亢進を含む様々な病的状態の治療において、薬学的組成物を調製するために使用される。【選択図】なし