GOLDSTEIN, DAVID MICHAEL,GONG, LEYI,MICHOUD, CHRISTOPHE,PALMER, WYLIE SOLANG,SIDDURI, ACHYUTHARAO
申请号：
ES07803049
公开号：
ES2378577T3
申请日:
2007.08.30
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein R is lower alkyl, hydroxy-lower alkyl, or a moiety selected from: wherein each Ra is independently H, lower alkyl, OH or hydroxy- lower alkyl； each Rb is independently H, lower alkyl, halogen, nitro or halo-lower alkyl； p is the number 1, 2, 3 or 4； X is O, CR4R5, C (= O) or S (O) x； R1 is hydrogen, halogen, alkyl or NH2； each of R3 is independently halogen, -NO2, lower alkyl, -CN, -OR7, -NR8R9, -C (O) -R7, -OC (O) - R7, -CF3, -CHF2, -SO2-R10 , or two of R3 form alkylene dioxy； R4 is hydrogen, lower alkyl, cyano, - (CH2) nOR7, - (CH2) nNR8R9, - (CH2) nC (O) -NR8R9, - (CH2) n-OC (O) -NR8R9, - (CH2) nC (O) -OR7； -NR7-SO2-R10, - (CH2) n-NR8-C (O) -R11 or - (CH2) n-NR8-C (O) -OR620； R5 is hydrogen or alkyl； or R4 and R5 together form alkylene dioxy； R6 is hydrogen, lower alkyl, heteroalkyl, cycloalkyl, heterocyclylalkyl or -NR8R9； R10 is alkyl, cycloalkyl, heterocyclylalkyl or -NR8R9； R 11 is alkyl, cycloalkyl, heteroalkyl or (heterocyclyl) alkyl； R2 and R7 are independently hydrogen or lower alkyl； R8 is hydrogen, lower alkyl, or acyl； R9 is hydrogen, lower alkyl, heteroalkyl, aryl, heteroaryl, heterocyclyl, cycloalkyl； or R8 and R9 together with the nitrogen atom to which they are attached form a heterocyclyl containing at least one nitrogen atom in the ring, optionally substituted by OH, oxo, lower alkyl, lower alkoxy or acyl； each of m and x is independently an integer from 0 to 2； Y is hydrogen, - (CH2) n-OR7, - (CH2) n-C (O) -R7 or - (CH2) n-C (O) -OR7； each of y and z is independently the number 0 or 1； and n is an integer from 0 to 4, and lower alkyl refers to an alkyl group with one to six carbon atoms.Un compuesto de la fórmula: o una sal farmacéuticamente aceptable del mismo, en la que R es alquilo inferior, hidroxi-alquilo inferior, o un resto elegido entre: en los que cada Ra es con independencia H, alquilo inferior, OH o hidroxi-alquilo inferior； cada Rb es con independencia
