ASTEX THERAPEUTICS LIMITED;GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
DAVE NORMAN DEATON,JOELLE LE,STEPHEN ANDREW THOMSON,JOSEPH WENDELL WILSON,ASHLEY PAUL HANCOCK,SIMON TEANBY HODGSON,GORDON SAXTY,PAUL N. MORTENSON,IAN EDWARD DAVID SMITH,HEATHER HOBBS,CHRISTIE SCHULTE
申请号：
ARP160103847
公开号：
AR107044A1
申请日:
2016.12.15
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
A compound quinolin-1 - 3 - carboxamide which has the formula (1), wherein, r u00b9 u1d43 is selected from: H, F, CL, Oh, - och u2083 c u2081 substituted alkoxy, and 1 to 3 times with Fluorine； r u00b2 u1d43 is selected from h,:F, CL, BR, I, - Oh, - C (o) oC (ch u2083) u2083, - COOH, - C (o) c u2081 u208b u2084 alkyl, - C (o) c u2081 u208b u2084 substituted alkyl with 1 to 5 substituents independently selected from: Fluorine, Chlorine, Bromine, Oxo, - Oh and - CN,Alkyl c u2081 u208b u2084 - S, - S - c u2081 u208b u2084 alkyl, substituted with 1 to 5 substituents independently selected from: Fluorine, Chlorine, Bromine, Oxo, - Oh and - CN, - S (o) alkyl c u2081 u208b u2084,- S (o) c u2081 u208b u2084 substituted alkyl with 1 to 5 substituents independently selected from: Fluorine, Chlorine, Bromine, Oxo, - Oh and - CN, - n u2083 c u00ban c u2081 u208b u2084 alkoxy -,,,C u2081 u208b u2084 alkoxy substituted with 1 to 5 substituents selected regardless of: Fluorine, Chlorine, Bromine, Oxo, - Oh and - CN, alkyl c u2081 u208b u2086,C u2081 u208b u2086 substituted alkyl with 1 to 5 substituents selected regardless of: Fluorine, Chlorine, Bromine, iodine, Oxo, alkoxy c u2081 u208b u2084, - Oh, - COOH, - nh u2082, - N (H) c u2081 u208b u2084 alkyl, N - (alkyl c u2081 u208b u2084) u2082 and CNCiclopropilo, ciclobutilo, 2.2 - difluorociclopropilo, pirrolidinilo, azetidinilo,Azetidinilo and replaced with one or two substituents independently selected from Halogen and methyl； r u00b3 u1d43 is selected from: H, F, CL, BR, I, - Oh, - C (o) oC ( u2083, - COOH, ch u2083)- C (o) c u2081 u208b u2084 alkyl, - C (o) c u2081 u208b u2084 substituted alkyl with 1 to 5 substituents independently selected from: Fluorine, Chlorine, Bromine, Oxo, - Oh and - CN, - S - S - c u2081 u208b u2084 alkyl, alkyl c u2081 u208b u2084,Substituted with 1 to 5 substituents independently selected from: Fluorine, Chlorine, Bromine, Oxo, - Oh and - CN, - S (o) alkyl c u2081 u208b u2084,- S (o) c u2081 u208b
