The Invention relates to a monolayer compressed for use in the treatment of tuberculosis, comprising a mixture of: (a) Granules containing Pyrazinamide, isoniazid, Ethambutol or a pharmaceutically acceptable Salt and at least one Binder granulation, in the form of rifampicin Dust, extragranulares excipients.The Granules have a particle size that is less than 0599 mm, preferably less than 0.5 mm, more preferably less than 0.422. It also refers to the process of preparation, characterized in that it comprises a step of Wet granulation of isoniazid, pyrazinamide and Ethambutol with an aqueous solution of a Binder granulation to obtain GranulesLa invencion se refiere a un comprimido monocapa para uso en el tratamiento de la tuberculosis que comprenden una mezcla de: a) granulos que comprenden isoniazid, pirazinamida, etambutol o una sal farmaceuticamente aceptable de este y al menos un aglutinante de granulacion, rifampicina en forma de polvo, excipientes extragranulares, en el que todos los granulos tienen un tamano de particula que es menor de 0,599 mm, preferiblemente menor de 0,5 mm, mas preferiblemente menor de 0,422 mm. Tambien se refiere a su proceso de preparacion caracterizado porque comprende una etapa de granulacion humeda de isoniazid, pirazinamida y etambutol con una disolucion acuosa de un aglutinante de granulacion para obtener granulos
