Joan Mazzarelli SOPCZYNSKI;Charles C. REED;INTREXON CORPORATION;Chi ZHANG;Gregory Ian FROST
发明人:
CHARLES C. REED,GREGORY IAN FROST,JOAN MAZZARELLI SOPCZYNSKI,CHI ZHANG
申请号：
US15511956
公开号：
US20170291934A1
申请日:
2015.09.21
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to modified forms of IL-12. These modified forms of IL-12 may be engineered to have a shortened in vivo half-life compared and/or enhanced localization of biological effects compared to that of corresponding non-modified form of IL-12. Short half-life and membrane bound forms of IL-12 may provide greater therapeutic control for in vivo therapeutic delivery, in particular when used in combination with ligand inducible delivery of IL-12. Modified forms of IL-12 engineered to have shortened in vivo half-life and/or enhanced localization of biological effects include heterodimeric p35/p40, single chain and membrane bound forms of IL-12 wherein a naturally occurring IL-12 amino acid sequence is genetically modified to enhance susceptibility of the IL-12 molecule to in vivo proteolytic degradation.
