DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS

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专利权人:

WILLIAM MARSH RICE UNIVERSITY

发明人:

NICOLAOU, KYRIACOS, C.,LU, MIN,MANDAL, DEBASHIS,GANGWAR, SANJEEV,CHOWDARI, NAIDU, S.,POUDEL, YAM, B.

申请号：

SG11201601047S

公开号：

SG11201601047SA

申请日:

2014.08.14

申请国别(地区):

SG

年份:

2016

代理人:

摘要：

In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).

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中国工程科技知识中心

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http://www.ckcest.cn/home/