Kyriacos C. NICOLAOU,Min LU,Debashis MANDAL,Sanjeev GANGWAR,Naidu S. CHOWDARI,Yam B. POUDEL
申请号：
US14911881
公开号：
US20160185791A1
申请日:
2014.08.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).
