The present invention relates to the spiral shell oxindole compounds of disease or morbid state that the sodium channel that such as pain is treated and/or prevented with what mediates, or mixtures thereof stereoisomer, enantiomter, tautomers Or its pharmaceutically acceptable salt, solvate or prodrug.本發明涉及用於治療和/或預防諸如疼痛的鈉通道介導的疾病或疾病狀態的螺羥吲哚化合物,其立體異構體、對映異構體、互變異構體或其混合物;或其藥物可接受的鹽、溶劑化物或前藥。