MIYAZAWA, SHUHEI,宫泽修平,宮澤修平,SHINODA, MASANOBU,筱田昌信,篠田昌信,KAWAHARA, TETSUYA,川原哲也,WATANABE, NOBUHISA,渡边信久,渡邊信久,HARADA, HITOSHI,原田均,IIDA, DAISUKE,饭田大介,飯田大介,TERAUCHI, HIROKI,寺内广毅,寺內廣毅,NAGAKAWA, JUN
申请号：
TW095113357
公开号：
TWI439270B
申请日:
2006.04.14
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The project of the present invention provides a kind of compounds in what, it is as starting because the treatment or prevention agent of the disease of what gastric acid is very useful, duration with excellent gastric acid secretion inhibiting effect and rich in gastric acid secretion inhibiting effect, pH in stomach can be made to continue higher, object chemical stability safer and with appropriateness for a long time. That is, the following general formula shown in compound or its salt or this etc. solvate:In formula, R1 and R3 is identical or different hydrogen atom or C1-6 alkyl, R2 is (5,5- dimethyl-1,3- dioxanes-2- base) methoxyl group, 5,7- bis- dislikes spiral shell [2.5] octyl- 6- ylmethoxy, 1,5,9- tri- dislikes the 11-3- ylmethoxy of spiral shell [5.5], (2,2- dimethyl-1,3- dioxanes-5- base) methoxyl group etc., R4, R5, R6 and R7 are hydrogen atom, halogen atom, C1-6 alkyl, C1-6 alkylhalide group, C1-6 alkoxy or C1-6 alkyl groups in the halogenalkoxy etc., and W1 is singly-bound, methylene or stretches ethyl.本發明之課題在於提供一種新穎化合物，其作為肇因於胃酸之疾病的治療或預防劑甚為有用，具有優異之胃酸分泌抑制作用且富有胃酸分泌抑制作用之持續性，可長時間使胃內pH持續較高，更為安全並具有適度之物化學安定性。即，下述通式所示之化合物或其鹽或是該等之溶劑合物：式中，R1及R3為相同或相異之氫原子或C1－6烷基，R2為(5,5－二甲基－1,3－二噁烷－2－基)甲氧基、5,7－二噁螺[2.5]辛－6－基甲氧基、1,5,9－三噁螺[5.5]十一－3－基甲氧基、(2,2－二甲基－1,3－二噁烷－5－基)甲氧基等，R4、R5、R6及R7為氫原子、鹵素原子、C1－6烷基、C1－6鹵烷基、C1－6烷氧基或C1－6鹵烷氧基等，W1為單鍵、亞甲基或伸乙基。
