New spiral shell (3H- indoles -3,2 -pyrrolidines) -2 (1H) -one compounds and its derivative as MDM2-P53 inhibitor

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专利权人:

BOEHRINGER INGELHEIM INTERNATIONAL GMBH

发明人:

ANDREAS GOLLNER,ANNIKA GILLE,CHRISTIANE KOFINK,GUENTHER HUCHLER,HARALD WEINSTABL,JOACHIM BROEKER,JUERGEN RAMHARTER,MANUEL HENRY,NINA KERRES,STEFAN GOEPPER

申请号：

BR112018007155

公开号：

BR112018007155A2

申请日:

2016.10.07

申请国别(地区):

BR

年份:

2018

代理人:

摘要：

The present invention includes formula (I) compound, wherein group R1To R4、R7, A, D, E, F, V, W, X, Y, n, r and q it is as defined in claim 1, the purposes of its inhibitor as MDM2 p53 interactions, the pharmaceutical composition of such compound is included, as drug, especially as treating and/or prevent the purposes of the medicament of tumor disease and synthetic intermediate.

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