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METHOD FOR PRODUCING A POLYGLYCEROL NANOGEL FOR THE ENCAPSULATION AND RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCES
专利权人:
发明人:
Rainer Haag,Dirk Steinhilber,Wolfgang Friess,Sarah Hedtrich (Born Küchler),Madeleine Witting
申请号:
US14426713
公开号:
US20150283094A1
申请日:
2013.09.05
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A method for producing a polyglycerol nanogel is disclosed, the method comprising the following steps: Mixing an aqueous solution of first polyglycerol macromonomers, which are modified with a first reactive group, with an aqueous solution of second polyglycerol macromonomers, which are modified with a second reactive group, wherein the first reactive group and the second reactive group can react with each other forming a chemical bond transferring the mixture into an organic non-solvent and precipitation of a polyglycerol nanogel consisting of first polyglycerol macromonomers and second polyglycerol macromonomers which are covalently bound to each other. According to an aspect of the invention, the method is characterized in that the organic non-solvent is miscible with water and in that the method is carried out without adding surface-active substances.
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