Indiana University Research and Technology Corporation
发明人:
Dimarchi, Richard D.,Azriel, Julia,Kaur, Zach,Meyers, Jonathan,Parody, Todd,Zhao, Yan
申请号：
AU2011268327
公开号：
AU2011268327A1
申请日:
2011.06.16
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
Single chain insulin analogs are provided having high potency and specificity for the insulin receptor. As disclosed herein optimally sized linking moieties can be used to link human insulin A and B chains, or analogs or derivatives thereof, wherein the carboxy terminus of the B25 amino acid of the B chain is linked to the amino terminus of the Al amino acid of the A chain via the intervening linking moiety. In on embodiment the linking moiety comprises a polyethylene glycol of 6-16 monomer units and in an alternative embodiment the linking moiety comprises a non-native amino acid sequence derived form the IGF-1 C-peptide and comprising at least 8 amino acids and no more than 12 amino acid in length. Also disclosed are prodrug and conjugate derivatives of the single chain insulin analogs.
