Geoffrey P. O'Donoghue,Jasper Z. Williams,Wendell A. Lim
申请号：
US16483349
公开号：
US20190359678A1
申请日:
2018.02.08
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided are chimeric T cell antigen receptors (TCR) comprising modified TCR chains. The modified TCR chains include fusion polypeptides having one or more heterologous antigen-binding domains fused to the extracellular domain of the TCR chain. Modified TCR chains also include chains that are modified in various other ways including e.g., chain truncation, cysteine modification, domain swapping and combinations thereof. Also provided are nucleic acids encoding the modified TCR chains as well as nucleic acids encoding the chimeric TCRs and recombinant expression vectors comprising such nucleic acids. Immune cells that are genetically modified or otherwise include the described chimeric TCRs, recombinant expression vectors encoding chimeric TCRs, and/or the described nucleic acids are also provided. Methods are also provided, such as methods of killing a target cell and/or treating a subject for a condition, e.g., through the use of the described chimeric TCRs, nucleic acids, expression vectors and/or immune cells.
