Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity

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专利权人:

Eric E. Swayze

发明人:

Eric E. Swayze,Andrew M. Siwkowski

申请号：

US12936156

公开号：

US08846639B2

申请日:

2009.04.03

申请国别(地区):

US

年份:

2014

代理人:

摘要：

In certain embodiments, the present invention provides oligomeric compounds having favorable toxicity profiles and therapeutic indexes. Compounds of the present invention comprise bicyclic nucleosides. Certain such bicyclic nucleosides are pyrimidines that do not include a methyl group at the 5-carbon. Oligomeric compounds comprising such nucleosides are less toxic than compounds comprising bicyclic nucleosides that do include a methyl group at the 5-carbon. In certain embodiments, the present invention provides methods of preparing and using such compounds.

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