The invention provides a skin care composition and a manufacturing method thereof. The skin care composition includes: micro molecular water, ion compounds, vitamins, amino acids, a carbon source and tetrahydro-methylpyrimidine carboxylic acid. The invention mainly makes use of the high permeability and the function of conditioning the growth of keratinocyte cells of the skin care composition to greatly increase the moisture content in the skin and reduce the surface water evapotranspiration at the same time, wherein its pH value is close to that of the tissue fluid of human body, as a result, it has the advantages of high biocompatibility and low exclusivity after the skin care composition penetrates into the skin.本發明係為一種護膚組合物及其製造方法，護膚組合物，包括：小分子水、離子化合物、維生素、胺基酸、碳源及四氫甲基嘧啶羧酸。本發明主要係藉由護膚組合物所具有之高滲透性及調控角質細胞生長的作用，同時可大幅提高肌膚含水量與減少表面水分蒸散，且其酸鹼值與人體組織液相近，因此在滲透入肌膚後有高生物相容性與低排他性的優點。
