TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;ARGINETIX, INC.
发明人:
CHRISTIANSON, DAVID W.,TOMCZUK, BRUCE EDWARD,POTTORF, RICHARD SCOTT,COLASANTI, ANDREW VARGHA,OLSON, GARY LEE
申请号：
CA2749853
公开号：
CA2749853C
申请日:
2010.01.26
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention is directed to arginase inhibitorcompounds of formula IA or formula IB: HoN,.Xi,xi H9N,.X1., .chi.{ xz ^zX "x2 ^ z R 1 R 1 K COOH COOH IA IB or a pharmaceutically acceptablesalt thereof, compositions containing these compounds, andmethods of their use for the treatment and diagnosis of conditionscharacterizedby upregulation of arginase, abnormally high arginase activity,or by abnormally low nitric oxide synthase activity.
