Susan Marie Lehman;Andres J. Garcia;Rodney Martin Donlan
发明人:
Rodney Martin Donlan,Susan Marie Lehman,Andres J. Garcia
申请号：
US14119716
公开号：
US09457132B2
申请日:
2012.06.28
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Medical devices that are resistant to biofilm development and methods of the manufacture of biofilm resistant medical devices are provided. One or more bacteriophages are tethered to the surface of a medical device or a hydrogei-type coating on the surface of the device by covalent bonding while maintaining bacteriophage infective or lytic activity. The presence of the bacteriophages on a medical device, such as an indwelling medical device, prevents biofilm formation or reduces existing biofilm formation on the surface of the device when in use. These devices address the long felt need for biofilm resistant devices that increase safety and reduce complications normally associated with prior indwelling or other medical devices.
