1. Description of the pyridan derivatives with chemical formula structure (1)；There is also a preparation procedure, drug synthesis containing these substances, and inhibitors for the treatment of phosphoric acid 3-500 (PI3Ks). These compounds can be used to treat cardiovascular disease, diabetes, flammable or autoimmune diseases and EPOC. Requirement 1: a formula compound (1),Or a salt, or solution, or nitrous oxide, or stereoisomer, or derivative thereof, wherein X represents a nitrogen atom, w represents a group-cr6 and Z represents a group-cr7； or X represents a group-cr5, w represents a nitrogen atom, Z represents a group-cr7； or X represents a group-cr5, W represents a group - Cr6 and Z represents a nitrogen atom； each RA and Rb represents a hydrogen atom, a C1-4 halogenated tar group, a C1-4 water oxidation group or a C1-4 linear tar or branch group independently； n represents 0, 1, 2 or 3； R1 represents a linear tar or branch group C1-4,C3-10 cyclopropyl compound, c3-10 cyclopropyl compound, c3-10 cyclopropyl compound, C6-14 monocyclic or bicyclic arilo group, 5-14 monocyclic or bicyclic heterogroups, at least one of which is heteroatom selected from O, s and N, A single ring or double ring heterocyclic heterocyclic heterocyclic group of 5 to 14 members containing at least one heterocyclic atom selected from O, s, and N, or a 2-piridona group in which the cyclopropene, cyclopropene, arilo, isopropene, and isopropene groups are not replaced or replaced by one or more substitutes selected from one halogen atom. 1. Hydroxy compound, one cyanide group, one C1-4 linear tar or branch group, one C1-4 halogenated tar group,Or (or) a group-2-2 (or) a group-2-2-2-2 (or) a group-0-2 (or) a group - (CH2) 0-3-n7r8； R2 represents a hydrogen atom, a halogen atom, a group Hydrogen Xi, one cyanide group, one alcox C1-4, one C1-4 halide group, one C1-4 hydrochemistry group, one c3-7 cyclic electrochemistry group, one NR rsqoe group, one R rsqoe rsqoe group；,Or a group o
