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PDE10 inhibitors of 1,3 - replaced.
专利权人:
MERCK SHARP & DOHME CORP.
发明人:
申请号:
ARP120103729
公开号:
AR088258A1
申请日:
2012.10.05
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
This product is aimed at alternative Azerbaijani compounds that can be used as drugs for the treatment of central nervous system disorders related to phosphate 10 (PDE10). It also refers to the use of these compounds in the treatment of neurological and psychiatric diseases, such as schizophrenia, psychosis or Huntington's disease, as well as diseases related to low estrogen or matrix necrosis. 1. Claim 1: a formula compound (1),Among them, x1,X2 and X3 are ch or n independently; R is selected from group H and c832131 asphalt;R² is selected from the group consisting of H, O-C₁₋₆ alkyl,1. Lease land No. c833218331 and 832626;Halogenated tar c83218323;(CH) -cicloalquilo CCN; (CH₂) ₙ-C₅₋₁₀ heterocycle,1-3 r74911 grade alternative asphalt, cyclopropene and other alternative heterocycles;R3 was selected from NRC (o) r8310a group;C (O) ORC (O) NR⁶R⁶ and (CH₂) ₙ-heterocycle C₅₋₁₀,a. It can be replaced by 1 to 3 r74919 classifications;R es (CH) -arilo C(CH₂) ₙ-C₅₋₁₀ heterocycle,(CH) -cicloalquilo CThese cyclopropene, isopropene and non propene replaced 1-3 r74911 groups;R⁶ is selected from the groups consisting of H, C₁₋₆ alkyl,OR (CH) -cicloalquilo C-NH (CH) -OR (CH) -arilo C-N (R)(CH₂) ₙ-C₆₋₁₀ heterocycle,1. These asphalts, cyclopentadiene, heterocyclic and optional arilo were replaced by 1 to 3 r74919 groups;Rᵃ is selected from the group consisting of: (i) halogen, (ii) hydroxyl, (iii) C₁₋₆ alkyl,1-3 R74955 was not replaced or substituted;(iv) -O-C₁₋₆ alkyl,1-3 R74955 was not replaced or substituted;(V) (CH) -arilo C1-3 R74955 was not replaced or substituted;(vi) -O- (CH₂) ₙ-C₅₋₁₀ heterocycle,1-3 R74955 was not replaced or substituted;(vii) - (CH₂) ₙ-C₅₋₁₀ heterocycle,1-3 R74955 was not replaced or substituted;(Viii) -O- (CH) -arilo C1-3 R74955 was not replaced or substituted;(Ix) - (CH) -arilo C1-3 R74955 was not replaced or substituted;(X) -O- (CH) -cicloalquilo C1-3 R74955 was not replaced or substituted;(Xi) - (CH) -cicloalquilo C1-3 R74955 was not replaced or substi
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