The present invention relates to a method of preparing a povidone-iodine complex as a human body sterilizing and disinfecting agent which is expected to obtain a lasting effect of strong oxidizing power of ions of the povidone-iodine complex prepared by adding nonvolatile solvents. The purpose of the present invention is to provide the method of preparing the povidone-iodine complex as the human body sterilizing and disinfecting agent, the povidone-iodine complex which enables povidone-iodine to destroy a cell-membrane protein of microorganisms by strong oxidizing power, and which not only interrupts absorption of iodine in the human body, but also prevents a problem that sterilizing power of the povidone-iodine complex is decreased when the povidone-iodine complex is coated after water is evaporated from the povidone-iodine complex although the povidone-iodine complex has a sterilizing power about three times larger than an alcohol component-containing cleaning agent generally used. To achieve the purpose, the method of the present invention comprises: drying a mixture of povidone and iodine in a vacuum state of 42 to 72°;C to prepare a povidone-iodine complex; and containing nonvolatile solvents as plant extracts such as canola oil, olive oil, grape seed oil, edible oil, corn oil and the like in the povidone-iodine complex such that the nonvolatile solvents are coated on skin to interrupt absorption of iodine into a human body and last strong oxidizing power by lasting an moisturizing effect. The method according to the present invention proves wide sterilization effects in adenovirus, norovirus, avian influenza virus, super bacteria, tuberculous bacillus and the like, exhibits a sterilization effect of 99.99% in Ebola virus, and also has effects in antivirus of SARS coronavirus that are the same series as MERS virus or coronavirus by strong oxidizing power of ions of the povidone-iodine complex.COPYRIGHT KIPO 2018[기술분야] : 본 발명은 비휘발성 용제를 첨가하여 제조한 포요드 복합물 이온의 강력