A method for interferential current stimulation by complex active regions, in which the method is adapted to generate low frequency interference active regions formed of staggered electric flux lines by disposing electrodes to stimulate specific parts of a human body by supplying electricity is provided. The method includes following steps: providing a power supply section configured to supply power having two different frequencies including a first frequency power source and corresponding electrical wires thereof and a second frequency power source and corresponding electrical wires thereof; and providing an electrode disposing section configured to provide plural electrodes respectively connected to the first frequency power source and the second frequency power source via the corresponding electrical wires, and interfere each other for generating plural low frequency active regions provided for stimulating a specific part of the human body to achieve the effect of curing various symptoms and muscle trainings.