TENDLER MIRIAM,VILAR MONICA MAGNO,ARMOA GERALDO RODRIGUES GARCIA,MCINTOSH DUGLAS,SIMPSON ANDREW J G
申请号：
IN7270/CHENP/2011
公开号：
IN2011CN07270A
申请日:
2011.10.07
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention relates to a vaccinal strain of recombinant BCG Mycobacterium bovis expressing the Schistossoma mansoni Sml4 protein (BCG Pasteur ?leuD/p?K410- hsp60-Sml4). The vaccinal strain of the present invention is employed in the control of infections caused by parasites, specially the Schistossoma mansoni. The vaccinal strain is a an auxotrophic strain to leucine amino acid derived from the BCG Pasteur sub-strain complemented to leucine after genetic transformation with the construct p?K410-hsp60- Sml4. The efficacy of the BCG Pasteur ?leuD/p?K410-hsp60-Sml4 strain in the control of the Schistossoma mansoni infection based on the recombinant Sml4 antigen in vivo is showed in the present invention.
