Monica Magno Vilar;Douglas Mcintosh;Andrew J.G. Simpson;Geraldo Rodrigues Garcia Armoa;Miriam Tendler
发明人:
Miriam Tendler,Monica Magno Vilar,Geraldo Rodrigues Garcia Armoa,Douglas Mcintosh,Andrew J.G. Simpson
申请号：
US13255734
公开号：
US20120093774A1
申请日:
2010.03.10
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to a vaccinal strain of recombinant BCG Mycobacterium bovis expressing the Schistossoma mansoni Sm14 protein (BCG Pasteur ΔleuD/pΔK410-hsp60*-Sm14). The vaccinal strain of the present invention is employed in the control of infections caused by parasites, specially the Schistossoma mansoni. The vaccinal strain is a an auxotrophic strain to leucine amino acid derived from the BCG Pasteur sub-strain complemented to leucine after genetic transformation with the construct pΔK410-hsp60*-Sm14. The efficacy of the BCG Pasteur ΔleuD/pΔK410-hsp60*-Sm14 strain in the control of the Schistossoma mansoni infection based on the recombinant Sm14 antigen in vivo is showed in the present invention.
