TENDLER MIRIAM,VILAR MONICA MAGNO,ARMOA GERALDO RODRIGUES GARCIA,MCINTOSH DOUGLAS,SIMPSON ANDREW J G
申请号：
AP2011005916
公开号：
AP3794A
申请日:
2010.03.10
申请国别(地区):
AP
年份:
2016
代理人:
摘要：
The present invention relates to a vaccinal strain of recombinant BCG Mycobacterium bovis expressing the Schistossoma mansoni Sm14 protein (BCG Pasteur ”leuD/p”K410-hsp60*-Sm14). The vaccinal strain of the present invention is employed in the control of infections caused by parasites, specially the Schistossoma mansoni. The vaccinal strain is a an auxotrophic strain to leucine amino acid derived from the BCG Pasteur sub-strain complemented to leucine after genetic transformation with the construct p”K410-hsp60*-Sm14. The efficacy of the BCG Pasteur ”leuD/p”K410-hsp60*-Sm14 strain in the control of the Schistossoma mansoni infection based on the recombinant Sm14 antigen in vivo is showed in the present invention.
