עיכוב בררני של אתר קישור משני של פעילות a–papp נגד 4–igfbp

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专利权人:

AARHUS UNIVERSITET

发明人:

申请号：

IL20715310

公开号：

IL207153A

申请日:

2010.07.22

申请国别(地区):

IL

年份:

2016

代理人:

摘要：

The present invention relates in one embodiment to PAPP-A exosite(s) interactors such as antibodies which bind to a region comprising LNR3 of PAPP-A and efficiently inhibit proteolysis of IGFBP-4, but not -5. The region comprising LNR3 represents a substrate binding exosite, which can be targeted for selective proteolytic inhibition. Accordingly, the present invention relates in one embodiment to differential inhibition of natural protease substrates by exosite targeting.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/