HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR ANTIGEN BINDING PROTEINS

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专利权人:

U3 PHARMA GMBH;AMGEN INC.

发明人:

ROTHE, MIKE,PRENZEL, NORBERT,BORGES, ERIC,ZWICK-WALLASCH, ESTHER,HETTMANN, THORE,FOORD, ORIT

申请号：

NZ58472608

公开号：

NZ584726A

申请日:

2008.09.26

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed is an isolated antibody or fragment thereof that specifically binds HB-EGF, comprising light chain complementary determining regions (CDRLs) CDRL1, CDRL2 and CDRL3 and heavy chain complementary determining regions (CDRHs) CDRH1, CDRH2 and CDRH3, wherein the isolated antibody or antibody fragment comprises a) a CDRL1 of SEQ ID NO: 207, a CDRL2 of SEQ ID NO: 225, a CDRL3 of SEQ ID NO: 257, a CDRH1 of SEQ ID NO: 292, a CDRH2 of SEQ ID NO: 323 and a CDRH3 of SEQ ID NO: 361； or b) a CDRL1 of SEQ ID NO: 210, a CDRL2 of SEQ ID NO: 221, a CDRL3 of SEQ ID NO: 260, a CDRH1 of SEQ ID NO: 292, a CDRH2 of SEQ ID NO: 320 and a CDRH3 of SEQ ID NO: 362； or c) a CDRL1 of SEQ ID NO: 213, a CDRL2 of SEQ ID NO: 230, a CDRL3 of SEQ ID NO: 263, a CDRH1 of SEQ ID NO: 293, a CDRH2 of SEQ ID NO: 324 and a CDRH3 of SEQ ID NO: 364.

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