HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR ANTIGEN BINDING PROTEINS农业专利-农业学术服务平台

发明人:: ROTHE, MIKE,PRENZEL, NORBERT,BORGES, ERIC,ZWICK-WALLASCH, ESTHER,HETTMANN, THORE,FOORD, ORIT

摘要：: Disclosed is an isolated antibody or fragment thereof that specifically binds HB-EGF, comprising light chain complementary determining regions (CDRLs) CDRL1, CDRL2 and CDRL3 and heavy chain complementary determining regions (CDRHs) CDRH1, CDRH2 and CDRH3, wherein the isolated antibody or antibody fragment comprises a) a CDRL1 of SEQ ID NO: 207, a CDRL2 of SEQ ID NO: 225, a CDRL3 of SEQ ID NO: 257, a CDRH1 of SEQ ID NO: 292, a CDRH2 of SEQ ID NO: 323 and a CDRH3 of SEQ ID NO: 361； or b) a CDRL1 of SEQ ID NO: 210, a CDRL2 of SEQ ID NO: 221, a CDRL3 of SEQ ID NO: 260, a CDRH1 of SEQ ID NO: 292, a CDRH2 of SEQ ID NO: 320 and a CDRH3 of SEQ ID NO: 362； or c) a CDRL1 of SEQ ID NO: 213, a CDRL2 of SEQ ID NO: 230, a CDRL3 of SEQ ID NO: 263, a CDRH1 of SEQ ID NO: 293, a CDRH2 of SEQ ID NO: 324 and a CDRH3 of SEQ ID NO: 364.