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TREATMENT OF STEROID-INDUCED HYPERGLYCEMIA WITH FIBROBLAST GROWTH FACTOR (FGF) 1 ANALOGS
专利权人:
Salk Institute for Biological Studies
发明人:
Ronald M. Evans,Michael Downes,Annette Atkins,Ruth T. Yu
申请号:
US15952516
公开号:
US20180228869A1
申请日:
2018.04.13
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Methods of using FGF1 analogs, such as FGF1 mutant proteins having an N-terminal deletion, point mutation(s), or combinations thereof, to reduce blood glucose levels in subjects with steroid-induced diabetes, hypercortisolemia, or diabetes due to treatment with an antipsychotic agent, are provided. Such mutant FGF1 proteins can be part of a chimeric protein that includes a β-Klotho-binding protein, an FGFR1-binding protein, a β-Klotho-binding protein and a FGFR1-binding protein, a C-terminal region from FGF19 or FGF21.
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http://www.ckcest.cn/home/
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