THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;ADVAXIS, INC.; INC.;ADVAXIS
发明人:
SHAHABI, VAFA,WALLECHA, ANU,MACIAG, PAULO C.,PATERSON, YVONNE,SEAVEY, MATTHEW,MASON, NICOLA
申请号：
CA2845583
公开号：
CA2845583A1
申请日:
2012.08.16
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
This invention provides compositions and methods for treating and vaccinating and inducing an immune response against a Her2/neu antigen-expressing tumor in a non-human animal. An exemplary method of treating a Her-2/neu-expressing tumor growth or cancer in a non-human animal, the method comprising the step of administering a recombinant Listeria comprising nucleic acid molecule encoding a fusion polypeptide, wherein said fusion polypeptide comprises a Her2/neu chimeric antigen fused to an additional adjuvant polypeptide is provided.
