BIEMANS, Barbara,GUBA, Wolfgang,JAESCHKE, Georg,LINDEMANN, Lothar,O'HARA, Fionn,RICCI, Antonio,RUEHER, Daniel,VIEIRA, Eric
申请号：
PE2017002337
公开号：
PE20180356A1
申请日:
2016.07.11
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
It refers to compounds extracted from formula (I), wherein R1 is low tar； R2 is phenyl or pyridine； n is 0-2； V and u are each or each or each CH2； L is an isomerization group composed of 5 or 6 elements, such as pyridine, pyridine, pyridazole, etc. The most popular compounds are: (8s) - 3 '- [2,6-difluoro-4 - (2-phenyl) phenyl] - 1' - methyl-helix [6,7-dihydro-5h-isocyano-8,6 '- Hexahydropyridine] - 2', 4 '- dioxin； (6S) - 3 - [2,6-difluoro-difluoro-4 - [2 - (3-pyridyl) etinil] - phenyl] - 1-methyl-helixThere are others He also mentioned a pharmaceutical composer These compounds are positive Western Sahara modulators of glucose-4 metabolite receptor (mGluR4), which can be used in the treatment of Parkinson's disease, anxiety, emeris disease and autism.SE REFIERE A COMPUESTOS DERIVADOS DE ETINILO DE FORMULA (I) DONDE R1 ES ALQUILO INFERIOR； R2 ES FENILO O PIRIDINILO； n ES DE 0 A 2； V Y U SON CADA UNO O U CH2； L ES UN GRUPO HETEROARILO DE CINCO O SEIS ELEMENTOS TAL COMO PIRIDINA, PIRIMIDINA, PIRAZOL, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (8S)-3'-[2,6-DIFLUORO-4-(2-FENILETINIL)FENIL]-1'-METIL-SPIRO[6,7-DIHIDRO-5H-ISOQUINOLIN-8,6'-HEXAHIDROPIRIMIDIN]-2',4'-DIONA； (6S)-3-[2,6-DIFLUORO-4-[2-(3-PIRIDIL)ETINIL]FENIL]-1-METIL-SPIRO[HEXAHIDROPIRIMIDIN-6,1'-TETRALIN]-2,4-DIONA； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES ALOSTERICOS POSITIVOS (MAP) DEL RECEPTOR METABOTROPICO DEL GLUTAMATO 4 (mGluR4) SIENDO UTILES PARA EL TRATAMIENTO DE LA ENFERMEDAD DEL PARKINSON, ANSIEDAD, EMESIS, AUTISMO
