The present invention relates to inhibiting the activity of non-genotype 1 hepatitis C virus (HCV) NS3-NS4A protease activity. More particularly, the invention relates to inhibiting the activity of the protease from HCV genotype-2 or HCV genotype-3. The methods of the invention emply inhibitors that act by interfering with the life cycle of the HCV and are also useful as antiviral agents. The invention further relates to compositions comprising such compounds either for ex vivo use or for administration to a patient suffering from genotype-2 or genotype-3 HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention.本發明係關於抑制非-基因型1之C型肝炎病毒(HCV)NS3-NS4A蛋白酶活性的活性。更特定而言,本發明係關於抑制得自HCV基因型-2或HCV基因型-3之蛋白酶的活性。本發明之方法係使用藉著干擾HCV之生命周期而發揮作用的抑制劑,亦可用來作為抗病毒製劑。本發明更關於組合物,其包括這類化合物,在活體外使用或投與罹患基因型-2或基因型-3HCV感染之患者。本發明亦關於藉著投與包括本發明之化合物的組合物,在患者中治療HCV感染的方法。