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Morpholinylquinazolines
专利权人:
Werner Mederski
发明人:
Werner Mederski,Thomas Fuchss,Frank Zenke
申请号:
US13581699
公开号:
US09126952B2
申请日:
2011.02.17
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The invention relates to compounds of the formulae (I), (II) and (III)in which R1, R2, R3, R4, Y, W1, W2, L, A, Alk, Cyc, Ar, Het1, Het2, Hal and n have the meaning indicated in Claim 1, and/or physiologically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. The compounds of the formula (I) can be used for the inhibition of serine/threonine protein kinases and for the sensitization of cancer cells to anticancer agents and/or ionizing radiation. The invention also relates to the use of the compounds of the formula (I) in the prophylaxis, therapy or progress control of cancer, tumors, metastases or angiogenesis disorders, in combination with radiotherapy and/or an anticancer agent. The invention furthermore relates to a process for the preparation of the compounds of the formula (I) by reaction of compounds of the formulae (II) and (III) and optionally conversion of a base or acid of the compounds of the formula (I) into one of their salts.
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