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Morpholinylquinazolines
专利权人:
MERCK PATENT GMBH
发明人:
Mederski, Werner,Fuchss, Thomas,Zenke, Frank
申请号:
AU2011229542
公开号:
AU2011229542A1
申请日:
2011.02.17
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The invention relates to compounds of the formulae (I), (II) and (III), where R1, R2, R3, R4, Y, W, W, L, A, Alk, Cyc, Ar, Het, Het, HaI and n have the meaning stated in claim 1, and/or physiologically harmless salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. The compounds of the formula (I) can be used for inhibiting serine-threonine protein kinases and also for sensitizing cancer cells to anticarcinogens and/or ionizing radiation. The invention also relates to the use of compounds of the formula (I) in prophylaxis, therapy or control of the progress of cancer, tumours, metastases or disorders of angiogenesis, in combination with radiotherapy and/or an anticarcinogen. The invention further relates to a method for producing compounds of the formula (I) by reacting compounds of the formulae (II) and (III) and optionally converting a base or acid of the compounds of the formula (I) into one of the salts thereof.
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