TOMAS Dzh. Rassell (IT),ТОМАС Дж. Расселл (IT),PERIKOT MOR Gal'.la (IT),ПЕРИКОТ МОР Галь.ла (IT),KARAMELLI K'jara (IT),КАРАМЕЛЛИ Кьяра (IT),MINETTO Dzhakomo (IT),МИНЕТТО Джакомо (IT),BELLINI Marta (IT,TOMAS DZH. RASSELL,ТОМАС Дж. Расселл,PERIKOT MOR GAL.LA,ПЕРИКОТ МОР Галь.ла,KARAMELLI KJARA,КАРАМЕЛЛИ Кьяра,MINETTO DZHAKOMO,МИНЕТТО Джакомо,BELLINI MARTA,БЕЛЛИНИ Марта
申请号：
RU2011150250/04
公开号：
RU0002533825C2
申请日:
2010.06.09
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to organic chemistry, namely to a heterocyclic compound of formula I and its pharmaceutically acceptable salt, wherein if a chemical valency permits, i represents 1 or 2, R1 represents H； a linear (C1-C4) alkyl group, R2 represents H, Cl or F, X represents either N, or CR3, R3 represents H； halogen； a linear (C1-C4) alkyl or (C1-C4) alkoxyl group, Y represents Z represents O or NRx, Rx represents H or a linear or branched (C1-C4) alkyl, k is equal to 2, 3 or 4, n and p independently represents 2, and a sum of n+p cannot exceed 4, T represents H or a linear (C1-C4) alkyl group； T′ represents a linear C1-C3 alkyl chain substituted by either (C1-C6)-dialkylaminogroup, or a 5-6-merous saturated heterocycle containing one nitrogen atom and optionally containing the second heteroatom specified in O, such a heterocyclic ring is optionally substituted by a (C1-C4) alkyl chain at nitrogen atoms； or a 5-merous saturated heterocycle containing one nitrogen atom, such a heterocyclic ring is optionally substituted by a (C1-C4) alkyl chain at nitrogen atoms； r represents zero, 1； R′ represents di(C1-C4)alkylamino, (C1-C4)alkoxy； except for the compounds specified in the clause. The invention also refers to a pharmaceutical composition based on the compound of formula (I), using the compound of formula (I) and to a method of treating diseases, in which the hedgehog signalling pathway modulation is effective.EFFECT: there are prepared new heterocyclic compounds possessing t effective biological properties.20 cl, 193 exИзобретение относится к области органической химии, а именно гетероциклическому соединению формулы I и его фармацевтически приемлемой соли, где, если валентность позволяет, i представляет собой 1 или 2, R1 представляет собой H； линейную (C1-C4) алкильную группу, R2 представляет собой H, Cl или F, X представляет собой либо N, либо CR3, R3 представляет собой H； галоген； линейную (C1-C4) алкильную или (C1-C4)
