NG Pui Ji (US),НГ Пуи Йи (US),BLUM Charl'z (US),БЛУМ Чарльз (US),MAKFERSON Loren (US),МАКФЕРСОН Лорен (US),PERNI Robert B. (US),ПЕРНИ Роберт Б. (US),VU Chi B. (US),ВУ Чи Б. (US),AKhMED Mokhammed Makhm,NG PUI JI,НГ Пуи Йи,BLUM CHARLZ,БЛУМ Чарльз,MAKFERSON LOREN,МАКФЕРСОН Лорен,PERNI ROBERT B.,ПЕРНИ Роберт Б.,VU CHI B.,ВУ Чи Б.,AKHMED MOKHAMMED MAKHMUD,АХМЕД Мохаммед Махмуд,DISH DZHEREMI S.,ДИШ Джере
申请号：
RU2012122065/04
公开号：
RU0002550821C2
申请日:
2010.10.29
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to the field of organic chemistry, namely to a compound of formula (I), or its tautomer, or a pharmaceutically acceptable salt, where each of Z1 and Z2: N and CR, where at least, one of Z1 and Z2 represents CR, and each R: H, C1-C4 alkyl and -N(R3)(R3)； W: -O-, -N(C1-C4) alkyl and -C(R6)(R6) -, and each R6: H and C1-C4 alkyl, or two R6, bound with the same carbon atom, are taken together with the formation of =O, R1: a phenyl and heterocycle, which represents a saturated or unsaturated 5-6-member monocyclic ring, containing 1-3 heteroatoms, selected from atoms N, S and O, or a 8-12-member bicyclic ring, each cycle of which is selected from a saturated, unsaturated and aromatic cycle, containing 1-2 nitrogen atoms, where R1 is optionally substituted with one or more substituents, independently selected from halogen, C1-C4 alkyl, =O, fluorosubstituted C1-C2 alkyl, -O-R3, -(C1-C4 alkyl)-N(R3)(R3), -N(R3)(R3) and -C(O)-N(R3)(R3), R2: a phenyl and heterocycle, which represents an unsaturated 5-6-member monocyclic ring, containing 1-2 heteroatoms, selected from atoms N and O, or represents dihydrobenzofuranyl, where R2 is optionally substituted with 1-2 substituents, independently selected from a halogen, -C≡N, C1-C4 alkyl, C1-C2 fluorosubstituted alkyl, -O-R3, -(C1-C4 alkyl)-N(R3)(R3) and -N(R3)(R3)； each R3: -C1-C4 alkyl； or two R3 are taken together with a nitrogen atom, which they are bound with, with the formation of a 4-8-member unsaturated heterocycle, optionally containing one additional heteroatom, selected from N and O, where in case when R3 represents an alkyl, the said alkyl is optionally substituted with two -OH groups, and when two R3 are taken together with a nitrogen atom, which they are bound with, with the formation of a 4-8-member saturated heterocycle, the said saturated heterocycle is optionally substituted with fluorine by any carbon atom； and is substituted with hydrogen by any capable of substitution n
