Bela Rajiv PATEL,Deborah SMITH,Deborah J. TOMPSON,Parnian ZIA-AMIRHOSSEINI
申请号：
US15729019
公开号：
US20180022799A1
申请日:
2017.10.10
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates generally to the methods for the treatment and diagnosis of conditions mediated by IL-5 and excess eosinophil production, and more specifically to mAbs, Fabs, chimeric and humanized antibodies. More particularly, methods are provided for reducing eosinophils in a human in need thereof, which method comprises administering to said human a composition comprising at least one anti-IL-5 antibody, wherein at least one anti-IL-5 antibody provides a mean maximum plasma concentration of said anti-IL-5 antibody of at least about 1.03±0.21 μg/mL, an Area Under the Curve(0-inf) value of at least about 15.5±2.7 μg*day/mL and a serum half-life of about 16.2±2.1 days to about 21.7±2.8 days.
