PATEL BELA RAJIV,SMITH DEBORAH,TOMPSON DEBRA J.,ZIA-AMIRHOSSEINI PARNIAN,PATEL Bela Rajiv,SMITH Deborah,TOMPSON Debra J.,ZIA-AMIRHOSSEINI Parnian
申请号：
SI200831253
公开号：
SI2152290T1
申请日:
2008.04.30
申请国别(地区):
SI
年份:
2014
代理人:
摘要：
The present invention relates generally to the methods for the treatment and diagnosis of conditions mediated by IL-5 and excess eosinophil production, and more specifically to mAbs, Fabs, chimeric and humanized antibodies. More particularly, methods are provided for reducing eosinophils in a human in need thereof, which method comprises administering to said human a composition comprising at least one anti-IL-5 antibody, wherein at least one anti-IL-5 antibody provides a mean maximum plasma concentration of said anti-IL-5 antibody of at least about 1.03 ± 0.21 µg/mL, an Area Under the Curve value of at least about 15.5 ± 2.7 µg/day/mL and a serum half-life of about 16.2 ± 2.1 days to about 21.7 ± 2.8 days.
