[PROBLEMS] To provide: a method for controlling the half-life of an anti-glypican-3antibody in the plasma； a pharmaceutical composition comprising an anti-glypican-3antibody having a controlled half-life in the plasma as an active ingredient；a method for producing the anti-glypican-3 antibody； and a method for producinga pharmaceutical composition comprising the anti-glypican-3 antibody as anactive ingredient. [MEANS FOR SOLVING PROBLEMS] Disclosed are: a method forcontrolling the half-life of an anti-glypican-3 antibody in the plasma by modifyingan amino acid residue exposed on the surface of the anti-glypican-3 antibody；an anti-glypican-3 antibody whose half-life in the plasma is controlled by themodification of an amino acid residue； a pharmaceutical composition comprisingthe antibody as an active ingredient； and a method for producing the pharmaceuticalcomposition.
