МЕТЦНЕР Хуберт (DE),ШУЛЬТЕ Штефан (DE),ВАЙМЕР Томас (DE)
申请号:
RU2015150040
公开号:
RU2015150040A
申请日:
2014.04.22
申请国别(地区):
RU
年份:
2017
代理人:
摘要:
The present invention relates to a covalent complex of von Willebrand Factor (VWF) and Factor VIII, wherein the complex is modified such that it has an extended half-life in vivo. The invention further relates to a method of producing the complex, as well as the therapeutic or prophylactic use of the complex for treating or preventing bleeding events.