immunogenic composition, method for producing an immunogenic composition, method for eliciting an immune response against neisseria, use of the immunogenic composition, and vaccine
JAN POLLMAN,JOHANNES PETRUS MARIA TOMMASSEN,MARTINE PETRONELLA BOS,MICHIEL STORK,VINCENT WEYNANTS
申请号：
BRPI0918226
公开号：
BRPI0918226A2
申请日:
2009.03.06
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bacterial antibodies are generated against said antigen. Methods are also provided to upregulate expression through removal of the zinc repression mechanism of the cell or promoter or through removal of zinc from the culture medium.
