GLAXOSMITHKLINE BIOLOGICALS S.A.;UNIVERSITY OF UTRECHT
发明人:
申请号：
EP09779121.4
公开号：
EP2331121B1
申请日:
2009.03.06
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bacterial antibodies are generated against said antigen. Methods are also provided to upregulate expression through removal of the zinc repression mechanism of the cell or promoter or through removal of zinc from the culture medium.
